Identifying hotspots of multidrug resistant tuberculosis transmission using spatial and molecular genetic data - Incite at Columbia University

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    Identifying hotspots of multidrug resistant tuberculosis transmission using spatial and molecular genetic data

  • Published July 14, 2015
  • Authors Jonathan L. Zelner Megan B. Murray Mercedes C. Becerra Jerome Galea Leonid Lecca Roger Calderon Rosa Yataco Carmen Contreras Zibiao Zhang Justin Manjourides Bryan T. Grenfell Ted Cohen
  • Category Paper
  • Forum Journal of Infectious Diseases
  • Link pmc.ncbi.nlm.nih.gov

A team of Robert Wood Johnson Foundation Health & Society Scholars, led by Dr. Jonathan Zelner, published a study in the Journal of Infectious Diseases.

The authors aimed to identify and determine the etiology of ‘hotspots’ of concentrated multi-drug resistant tuberculosis (MDR-TB) risk in Lima, Peru. Methods: From 2009-2012, we conducted a prospective cohort study among households of TB cases from 106 health center (HC) areas in Lima, Peru. All notified TB cases and their household contacts were recruited and followed for one year. Individuals with TB symptoms were screened by microscopy and culture; positive cultures were tested for drug susceptibility (DST) and genotyped by 24-loci MIRU-VNTR.

Findings reveal that localized transmission is an important driver of the epidemic of MDR-TB in Lima. Efforts to interrupt transmission may be most effective if targeted to this area of the city. 

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  • go to Health and Society Scholars
    Health and Society Scholars
    Promoting interdisciplinary research in population health through working groups, internal funding, and public events Funded by the Robert Wood Johnson Foundation

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